diff --git a/pytest.ini b/pytest.ini
--- a/pytest.ini
+++ b/pytest.ini
@@ -1,2 +1,3 @@
 [pytest]
 norecursedirs = docs
+DJANGO_SETTINGS_MODULE = swh.deposit.settings.testing
diff --git a/requirements-test.txt b/requirements-test.txt
--- a/requirements-test.txt
+++ b/requirements-test.txt
@@ -1,2 +1,2 @@
-nose
-django_nose
+pytest
+pytest-django
diff --git a/swh/deposit/settings/testing.py b/swh/deposit/settings/testing.py
--- a/swh/deposit/settings/testing.py
+++ b/swh/deposit/settings/testing.py
@@ -8,13 +8,10 @@
 from .development import *  # noqa
 from .development import INSTALLED_APPS
 
-# django-nose setup
+# django setup
 ALLOWED_HOSTS += ['testserver']
 
-INSTALLED_APPS += ['django_nose']
-
-TEST_RUNNER = 'django_nose.NoseTestSuiteRunner'
-NOSE_ARGS = ['--verbosity=3', '-s']  # to see test pass
+INSTALLED_APPS += ['pytest_django']
 
 # https://docs.djangoproject.com/en/1.10/ref/settings/#logging
 LOGGING = {
diff --git a/swh/deposit/tests/api/test_deposit_check.py b/swh/deposit/tests/api/test_deposit_check.py
--- a/swh/deposit/tests/api/test_deposit_check.py
+++ b/swh/deposit/tests/api/test_deposit_check.py
@@ -6,7 +6,7 @@
 import unittest
 
 from django.core.urlresolvers import reverse
-from nose.plugins.attrib import attr
+import pytest
 from rest_framework import status
 from rest_framework.test import APITestCase
 
@@ -26,7 +26,7 @@
 from ..common import FileSystemCreationRoutine
 
 
-@attr('fs')
+@pytest.mark.fs
 class CheckDepositTest(APITestCase, WithAuthTestCase,
                        BasicTestCase, CommonCreationRoutine,
                        FileSystemCreationRoutine):
diff --git a/swh/deposit/tests/api/test_deposit_list.py b/swh/deposit/tests/api/test_deposit_list.py
--- a/swh/deposit/tests/api/test_deposit_list.py
+++ b/swh/deposit/tests/api/test_deposit_list.py
@@ -4,7 +4,7 @@
 # See top-level LICENSE file for more information
 
 from django.core.urlresolvers import reverse
-from nose.plugins.attrib import attr
+import pytest
 from rest_framework import status
 from rest_framework.test import APITestCase
 
@@ -15,7 +15,7 @@
 from ...models import Deposit
 
 
-@attr('fs')
+@pytest.mark.fs
 class CheckDepositListTest(APITestCase, WithAuthTestCase,
                            BasicTestCase, CommonCreationRoutine):
     """Check deposit list endpoints.
diff --git a/swh/deposit/tests/api/test_deposit_read_archive.py b/swh/deposit/tests/api/test_deposit_read_archive.py
--- a/swh/deposit/tests/api/test_deposit_read_archive.py
+++ b/swh/deposit/tests/api/test_deposit_read_archive.py
@@ -7,7 +7,7 @@
 import os
 
 from django.core.urlresolvers import reverse
-from nose.plugins.attrib import attr
+import pytest
 from rest_framework import status
 from rest_framework.test import APITestCase
 
@@ -19,7 +19,7 @@
 from ..common import FileSystemCreationRoutine, create_arborescence_archive
 
 
-@attr('fs')
+@pytest.mark.fs
 class DepositReadArchivesTest(APITestCase, WithAuthTestCase,
                               BasicTestCase, CommonCreationRoutine,
                               FileSystemCreationRoutine):
diff --git a/swh/deposit/tests/common.py b/swh/deposit/tests/common.py
--- a/swh/deposit/tests/common.py
+++ b/swh/deposit/tests/common.py
@@ -13,7 +13,7 @@
 from django.core.urlresolvers import reverse
 from django.test import TestCase
 from io import BytesIO
-from nose.plugins.attrib import attr
+import pytest
 from rest_framework import status
 
 from swh.deposit.config import (COL_IRI, EM_IRI, EDIT_SE_IRI,
@@ -138,7 +138,7 @@
     return compute_info(invalid_archive_path)
 
 
-@attr('fs')
+@pytest.mark.fs
 class FileSystemCreationRoutine(TestCase):
     """Mixin intended for tests needed to tamper with archives.
 
@@ -264,7 +264,7 @@
         return deposit_id
 
 
-@attr('fs')
+@pytest.mark.fs
 class BasicTestCase(TestCase):
     """Mixin intended for data setup purposes (user, collection, etc...)
 
diff --git a/swh/deposit/tests/loader/test_client.py b/swh/deposit/tests/loader/test_client.py
--- a/swh/deposit/tests/loader/test_client.py
+++ b/swh/deposit/tests/loader/test_client.py
@@ -8,7 +8,7 @@
 import tempfile
 import unittest
 
-from nose.plugins.attrib import attr
+import pytest
 
 from swh.deposit.client import PrivateApiDepositClient
 from swh.deposit.config import DEPOSIT_STATUS_LOAD_SUCCESS
@@ -41,7 +41,7 @@
         return self.response
 
 
-@attr('fs')
+@pytest.mark.fs
 class PrivateApiDepositClientReadArchiveTest(unittest.TestCase):
     def setUp(self):
         super().setUp()
diff --git a/swh/deposit/tests/loader/test_loader.py b/swh/deposit/tests/loader/test_loader.py
--- a/swh/deposit/tests/loader/test_loader.py
+++ b/swh/deposit/tests/loader/test_loader.py
@@ -7,7 +7,7 @@
 import unittest
 import shutil
 
-from nose.plugins.attrib import attr
+import pytest
 from rest_framework.test import APITestCase
 
 from swh.model import hashutil
@@ -182,7 +182,7 @@
     pass
 
 
-@attr('fs')
+@pytest.mark.fs
 class DepositLoaderScenarioTest(APITestCase, WithAuthTestCase,
                                 BasicTestCase, CommonCreationRoutine,
                                 FileSystemCreationRoutine, TestLoaderUtils):